A groundbreaking cell atlas that maps the entire mouse brain and records more than 32 million cells in detail opens the way to a deeper understanding of the human brain and the development of precision treatments for brain disorders. Masu.
An international team of researchers has created the first-ever complete cellular atlas of the entire mammalian brain. This atlas serves as a map of the mouse brain, describing the types, locations, and molecular information of more than 32 million cells, and providing information about the connections between these cells. Mice are the most commonly used vertebrate experimental model in neuroscience research, and this cellular map paves the way for a deeper understanding of the human brain, perhaps the world’s most powerful computer. . The Cell Atlas also lays the foundation for the development of a new generation of precision treatments for people with psychiatric and neurological disorders of the brain.
The results of this study were funded by: National Institutes of Health Brain research powered by innovative advances in neurotechnology® Initiativeor in a collection of 10 papers published in The BRAIN Initiative®. Nature.
“The Mouse Atlas brings unprecedented focus to the complex networks of mammalian brain cells, giving researchers the details they need to understand human brain function and disease,” said Dr. said Joshua A. Gordon, MD. Mental health is National Institutes of Health.
Detailed mapping of the mouse brain
The cell atlas describes the cell types in each region of the mouse brain and the organization of cells within those regions. In addition to this structural information, cell atlases provide an incredibly detailed catalog of a cell’s transcriptome (the complete set of genetic reads within a cell). It contains instructions for making proteins and other cellular products. The transcriptome information contained in the atlas is hierarchically organized, detailing cell classes, subclasses, and thousands of individual cell clusters in the brain.
This atlas also characterizes the cellular epigenome, or chemical modifications of the cell. DNA We then detail the chromosomes that change how a cell’s genetic information is expressed, the thousands of epigenomic cell types, and the millions of candidate gene control elements in different brain cell types.
Together, the structural, transcriptomic, and epigenetic information contained in this atlas provides an unprecedented map of cellular organization and diversity throughout the mouse brain. This atlas also provides a description of the neurotransmitters and neuropeptides used by different cells and the relationships between cell types in the brain. This information can be used as a detailed blueprint for how chemical signals are initiated and transmitted in different parts of the brain. These electrical signals are the basis for how the brain’s circuits operate and how the brain functions as a whole.
Pioneering collaborative efforts and future directions
“This product is a testament to the power of this unprecedented cross-disciplinary collaboration and paves the way for more precise brain treatments,” said Dr. John Guy, director of the NIH BRAIN Initiative. .
Of the 10 studies included in this collection, seven were funded through the NIH BRAIN Initiative Cell Census Network (BICCN) and two were funded through the larger NIH BRAIN Initiative. The central purpose of BICCN is to create a comprehensive inventory of the cells in the brain, a groundbreaking, collaborative effort to understand the cellular composition of the brain. That is, where they are located, how they develop, how they work together, and how they function. By modulating brain activity, we can better understand how brain disorders develop and progress, and how best to treat them.
“By leveraging the unique nature of interdisciplinary and international collaboration, BICCN has been able to achieve what no other team of scientists has been able to achieve to date,” said Dr. Ngai. “Now we are ready to take the next big step in completing the cellular maps of the human and non-human primate brains.”
The BRAIN Initiative Cell Atlas Network (BICAN) is the next step in the NIH BRAIN Initiative’s efforts to understand cells and cell function in the mammalian brain. BICAN, along with two of his other large-scale projects, BRAIN Initiative Connectivity Across Scales and Armamentarium for Precision Brain Cell Access, will research neuroscience by uncovering fundamental principles governing the circuit basis of behavior and informing new approaches. It is an innovative project that aims to revolutionize the world. For the treatment of human brain diseases.
Reference: “High-resolution transcriptome and spatial atlas of cell types across the mouse brain” Zizhen Yao, Cindy TJ van Velthoven, Michael Kunst, Meng Zhang, Delissa McMillen, Changgy Lee, Won Jung, Jeff Goldy, Aliya Abdelhak, Matthew Aitken, Katherine Baker, Pamela Baker, Eliza Balkan, Darren Bertagnoli, Ashwin Bandiwad, Cameron Bielstein, Prajal Vishwakarma, Jazmine Campos, Daniel Carey, Tamara Casper, Anish Baswanth Chukka, Lucille Chakrabarty, Sakshi Chavan, Ming Chen, Michael Clarke, Jenny Close, Kirsten Crichton, Scott Daniel, Peter DiValentin, Tim Dolbear, Lauren Ellingwood, Elisha Fiabane, Timothy Frith, James Gee, James Gerstenberger, Alexandra Grandon, Jessica Groh, Joshua Gould, James Gray, Nathan Gilford, Junitta Gassman, Daniel Hirshstein, Windy Ho, Marcus Hooper, Mike Huang, Maddie Hupp, Kelly Jin, Matthew Kroll, Kanan Latia, Ariel Leung, Sue Li, Brian Long, Zach Madigan, Jessica Malloy, Jocelyn Malone, Zoe Maltzer, Naomi Martin, Rachel McCue, Ryan McGinty, Nicholas May, Jose Melchor, Emma Meyerdiaks, Tyler Molenkopf, Skylar Moonsman, Thuc Nguyen, Sven Otto, Tran Thanh Pham, Christine・Remorin, Augustin Ruiz, Raymond Sanchez, Lane Sawyer, Nadiya Shapovalova, Noah Shepherd, Cliff Sloterbeck, Joseph Suluk, Michael Tiu, Amy Torkelson, Herman Tan, Nasmir Varela Cuevas , Shane Vance, Katherine Wadhwani, Caitlin Ward, Boaz Levi, Colin Farrell, Rob Young, Brian Staats, Mingqiang Michael Wang, Carol L. Thompson, Shoaib Mufti, Chelsea M. Pagan , Lauren Kruse, Nick Dee, Susan M. Sunkin, Luke Esposito, Michael J. Hawrylycz, Jack Waters, Lydia Ng, Kimberly Smith, Bosiljka Tasic, Xiaowei Zhuang, Hongkui Zeng, December 13, 2023, Nature.
DOI: 10.1038/s41586-023-06812-z