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The key to feeling full may lie in vibrating capsules, according to a weight loss treatment study involving pigs and engineers at the Massachusetts Institute of Technology.
The pill, called Vibratory Ingestible BioElectronic Stimulator (VIBES for short), stimulates the nerve endings that sense stomach expansion, tricking the brain into thinking the stomach is full.
According to MIT Technology Review, “The capsule, about the size of a large vitamin, contains a small motor that begins to vibrate when it hits the stomach, stimulating the organ’s stretch receptors.”
Researchers found that when animals were given the drug 20 minutes before a meal, it stimulated the release of hormones that signal satiety, reducing food intake by about 40%. news release.
“People who want to lose weight or control their appetite may want to take it before each meal,” said Dr. Shriya Srinivasan, a former MIT graduate student and postdoctoral fellow who is now an assistant professor of bioengineering at Harvard University. . “This could be very interesting in that it provides an option that can minimize the side effects seen with other drug treatments.”
Srinivasan is the lead author of a new study published Friday in Science Advances, an “open access” journal of the American Association for the Advancement of Science.
The current version of VIBES is designed to vibrate for 30 minutes after arriving in the stomach, but researchers hope it could remain in the stomach for even longer with a feature that can be turned on and off wirelessly. I am planning to investigate gender.
In animal studies, tablets passed through the gastrointestinal tract in about 4 to 5 days.
“While the tablets were in the gastrointestinal tract, the animals showed no signs of obstruction, perforation, or other adverse effects,” the MIT release states.
![VIBES concept and mechanism.](https://nypost.com/wp-content/uploads/sites/2/2023/12/sciadvadj3003-f1-copy.jpg?w=793)
![VIBES concept and mechanism.](https://nypost.com/wp-content/uploads/sites/2/2023/12/sciadvadj3003-f1-copy.jpg?w=793)
VIBES researchers are now considering scaling up the production of the capsules, “which could potentially enable human clinical trials.”
Nowadays, celebrities and ordinary people are turning to drugs such as Ozempic, Wigoby, and Munjaro for weight loss.
Munjaro and Ozempic have been approved by federal health officials to lower blood sugar levels in adults with type 2 diabetes. However, given their weight loss effects, both drugs were used “off-label” to treat obesity, especially in the days when his Wegovy was difficult to obtain.
Wegovy and Ozempic contain the same active ingredient, semaglutide, but differ in dosage and FDA-approved uses.
Novo Nordisk’s Wigoby was approved by the FDA in 2021 for chronic weight management.
At the time, it was the first drug approved since 2014 for long-term weight management and quickly gained popularity.
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