Scientists have found that timing cancer treatment based on a patient’s biological clock may improve the treatment’s effectiveness. The study, conducted by researchers at the University of California, Irvine, found that the body’s natural 24-hour cycle influences the immune system’s ability to fight cancer. The researchers also found that disrupting circadian rhythms reduces the immune system’s ability to fight cancer. These findings suggest that both lifestyle changes and treatment timing may help fight cancer.
This study Nature Immunology,Providing deeper insight into the complex relationship between the circadian clock, immune regulation, and tumor development, we found that therapies that optimize time-of-day administration based on an individual’s unique circadian rhythm pattern could open new avenues for prevention and treatment.
“Disruption of the body’s biological pacemakers is an inherent aspect of modern society and may contribute to the rising incidence of many types of cancer. We find that proper regulation of circadian rhythms is necessary to reduce inflammation and support peak immune function.” Corresponding author Selma Masri said: “Understanding exactly how circadian rhythm disruption drives disease progression may lead to behavioral modifications that reduce cancer risk,” said Dr.
“As our understanding of the underlying mechanisms of circadian immune regulation improves, we may be able to harness the power of the body’s natural rhythms to fight cancer and develop more personalized and effective treatment strategies,” said lead author Brigitte Fortin, a doctoral student in the Department of Biological and Chemical Sciences at UC Irvine.
While this study represents a major step forward in defining circadian control of anti-tumor immunity, the team believes that future research should focus on investigating additional factors and cell types that influence time-of-day responses to checkpoint inhibitor therapy.